Seachem Freshwater Fish Medication Selector
compiled by The Pragmatic Aquarist on September 15, 2016
Use the following to select the medication most appropriate for your set up. Once you've picked something, confirm the selection by reading the official Seachem web page. Things change!
  Cupramine KanaPlex MetroPlex NeoPlex ParaGuard PolyGuard SulfaPlex
Highlights by Seachem - Copper reatment for external parasites
- Active at low concentration (does not precipitate)
- Bound on amine so it is not as toxic to fish
- 100% Removable with carbon or Cuprisorb
- Broad Spectrum Antibiotic
- Treats fungal and bacterial fish diseases
- Easily absorbed through both skin and gills; ingestion not required
- Treats protozoan parasites and anaerobic bacterial diseases
- Little danger of overdose
- No impact on bio-filter
- Well suited for medicated food mix for internal parasites
- Broad spectrum antibiotic effective against most external infections
- Safe for marine and freshwater
- Minimal impact on bio-filter
- Eradicates ectoparasites and fungal, bacterial, and viral lesions
- Safer to dose than formaldehyde, formalin, and methanol
- Will not adversely effect bio-filter
- Treats bacterial, fungal, and parasitic diseases
- Very broad spectrum freshwater medication
- Good choice when unsure of the disease
- Treats many bacterial, fungal, and protozoan infestations
- Broad spectrum antibiotic and anti-fungal medication
- Most effective of the sulfa drugs in saltwater
- Absorbed through gills
Parasitic Infections Yes   Yes   Yes Yes Yes
Fungal Infections   Yes   Yes Yes Yes Yes
Bacterial Infections   Yes Yes Yes Yes Yes Yes
Viral Infections         Yes    
Ailments Mentioned - Ich (White Spot, Ichthyophthirius)
-
Velvet (Piscinoodinium)
- Oodinium [mentioned in FAQ]
- Cryptocaryon [mentioned in FAQ]
- Amyloodinium [mentioned in FAQ]
- Gill Flukes (FAQ)
- Popeye
- Cloudy Eye
- Fin Rot
-
Mouth Rot (Columnaris)
-
Hemorrhagic Septicemia (Aeromonas hydrophilia)
- Dropsy
- Tropheus and Petrochromis with bloat [mention in FAQ]
- Ich (White Spot, Ichthyophthirius)
-
Velvet (Piscinoodinium)
- Hole in the Head / Head and Lateral Line Erosion (Spironucleus)
- Fin Rot (Bacterial Infection)
- Bacterial Lesions
- Mouth Rot (Columnaris)
- Bloat
- Ich (White Spot, Ichthyophthirius)
-
Velvet (Piscinoodinium)
-
Fin Rot (Bacterial Infection)
- Flukes (Dactylogyrus trematodes (skin)
- Flukes (Monogenenean trematodes (gills))
- Ich (White Spot, Ichthyophthirius)
-
Fin Rot (Bacterial Infection)
-
Mouth Rot (Columnaris)
-
Hemorrhagic Septicemia (Aeromonas hydrophilia)
-
Fungus
- Fin Rot (Bacterial Infection)
-
Mouth Rot (Columnaris)
-
Hemorrhagic Septicemia (Aeromonas hydrophilia)
-
Fungus
- Fur Coat Syndrome
Warnings - Use with other products including dechlorinators dangerous. - First round of treatment may stress fish limiting the possibility of a second round of treatment.          
Other Notes from Seachem - Flukes or Lymphocystis are mistaken for Ich, and these are better treated with ParaGuard.
- Complete removal from aquarium via Cupramine.
- Can be used with MetroPlex (mix with food) or Cupramine. - Can be used with KanaPlex (mix with food).
- Gentle so overdosing difficult.
  - It is particularly useful in hospital and receiving tanks for new fish and whenever new fish are introduced to a community tank. Use for 2 weeks in these scenarios. - PolyGuard is the single most effective medication to keep freshwater fish free of disease!
- Use whenever introducing new fish.
 
Safe for Plants* not mentioned not mentioned not mentioned Yes Yes not mentioned not mentioned
Safe for Inverts* No Yes (when used in medicated food mix) Yes (when used in medicated food mix) Yes Yes No No
Safe for Bio Filter not mentioned Yes Yes Yes Yes not mentioned not mentioned
Add to Food No Yes Yes Yes No No Yes
Add to Water Yes Yes Yes Yes Yes Yes Yes
Internal Ailments No Yes Yes        
External Ailments Yes   Yes Yes Yes    
* Seachem doesn't promise that all plants and/or invertebrates will be unharmed by a medication that is "safe". Instead, when something is marked as safe it means few or no reports from testing/customers of issues.